The global pandemic of Coronavirus has led to a rethink of people’s interaction with public spaces. As the spreading of infection is still not controlled, it is the role of spatial designers to figure out proper approaches for keeping social distance between people through spatial modification of public buildings as well as urban spaces. This study focuses on the reopening strategy of art museums in post-COVID-19 time, asking: what are the strategies for reopening adopted by museums and which spatial factors affect the adaptation of their layout and curatorial organisation? The purpose is to provide not only practical solutions but also a theoretical model for the future evaluation of the capability of museums for doing so. Building on Hillier’s theory of spatial types and spatial structures (Hillier 2019), four British museums have been chosen for the investigation of the socio-spatial changes implicated in their reopening process. These are: The National Gallery, Tate Britain, Tate Modern and The Wallace Collection. The Museum of Modern Art in New York is also explored in terms of the changes in its spatial layout brought about by successive strategies of expansion. The study attempts to have a more in-depth understanding of the role the spatial structure plays in the organisation of movement in art museums, both spatial and transpatial, based on the analytical findings. The study suggests that the use of d-spaces in spatial layouts is the determinant factor for the capability of museums to successfully respond to specialists’ guidance for the reopening. It also proposes a model for a multilayered spatial system in relation to the global-local network. On each layer, d-spaces present the particularity for the spatial configuration and transpatial intention in the meantime.