The main purpose of this study is to explore the general impact of centrality on urban space and to verify the relationship between the centrality structure in urban networks and the concrete centre and barrier areas in urban spaces. The core question of the research is: what is the potential impact of the integration-based centre, the functional centre and the physical barrier on the social-economic conditions of communities? Based on the question, this study takes 457 communities in central and northern London as case studies, and measure the spatial relation between the community and various adjacent centres and barriers with network analysis methods. On this basis, Multi-scale Geographically Weighted Regression(MGWR) and Binary Logistics Regression methods are employed to test the correlation between spatial relation and the socio-economic conditions of the local communities.